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Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

[ Vol. 15 , Issue. 10 ]

Author(s):

Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini   Pages 822 - 825 ( 4 )

Abstract:


A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

Keywords:

Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.

Affiliation:

Department of Chemistry, Faculty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad, Iran



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