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Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

[ Vol. 15 , Issue. 10 ]


Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini   Pages 822 - 825 ( 4 )


A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.


Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.


Department of Chemistry, Faculty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad, Iran

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