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Expeditious Solvent-Free Synthesis of Chromene Derivatives via Three- Component Reactions of N-Nucleophiles

[ Vol. 15 , Issue. 10 ]


Mohammad R. Hosseini-Tabatabaei and Faramarz Rostami-Charati   Pages 835 - 839 ( 5 )


Multicomponent reactions involving 4-hydroxycumarine, activated acetylenic compounds and N-nucleophiles under solvent-free conditions were investigated. The reactions could also be extended to quinoline or CH-acides. Substituted chromen could be obtained from this routine, which may have potential applications in drugs fields.


4-Hydroxy coumarin, acetylenic compounds, isoquinoline, one-pot reactions, solvent-free.


Department of Chemistry, Zahedan Branch, Islamic Azad University, Zahedan, Iran

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