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Novel 2-(2-Benzylidenehydrazinyl)Benzo[d]Thiazole as Potential Antitubercular Agents

[ Vol. 16 , Issue. 3 ]

Author(s):

Vinod Kumar Bairwa and Vikas N. Telvekar   Pages 244 - 247 ( 4 )

Abstract:


Molecular hybridization approach was used to synthesize substituted 2-(2-(4-aryl oxy benzylidene) hydrazinyl)benzo thiazole derivatives with 2-hydrazinobenzothiazole and 4-(alicycli/aryl/biaryl/heteroaryl oxy)benzaldehyde as new anti-TB agents. The synthesized compounds, when tested against H37Rv strains of Mtb using Resazurin Microtitre Assay (REMA) method, showed promising activity (MIC 1.35-36.50μg/mL). 6-chloro-2-(2-(4- (pyridin-4-yloxy) benzylidene) hydrazinyl) benzo[d]thiazole (10v) gave MIC of 1.35 μg/mL. Thus making it, a potential lead could be developed for further antitubercular studies.

Keywords:

(Aryloxy) benzaldehyde, anti-TB, benzothiazole, hybridization approach

Affiliation:

Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, India.



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