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Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

[ Vol. 16 , Issue. 10 ]

Author(s):

Zinatossadat Hossaini, Samereh Seyfi, Faramarz Rostami-Charati and Mehdi Ghambarian   Pages 788 - 790 ( 3 )

Abstract:


A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Keywords:

Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.

Affiliation:

Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.



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