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A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

[ Vol. 16 , Issue. 10 ]

Author(s):

Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng   Pages 858 - 864 ( 7 )

Abstract:


A Passerini-type condensation for the synthesis of α -acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.

Keywords:

Isocyanide, Passerini reaction, α-acyloxycarboxamides.

Affiliation:

Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.



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