Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan Pages 503 - 508 ( 6 )
A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.
Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.
Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.