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H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

[ Vol. 17 , Issue. 6 ]

Author(s):

Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan   Pages 503 - 508 ( 6 )

Abstract:


A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.

Keywords:

Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.

Affiliation:

Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.



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