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An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines

[ Vol. 19 , Issue. 3 ]

Author(s):

Mohammad Hosein Sayahi, Shirin Baghersaei, Fereshteh Goli, Setareh Moghimi, Mohammad Mahdavi, Loghman Firoozpour, Abbas Shafiee and Alireza Foroumadi   Pages 189 - 192 ( 4 )

Abstract:


Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.

Keywords:

N-N bond forming, Heterocyclization, Triazine, Quinazoline, Diazonium, Isatoic anhydride.

Affiliation:

Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.



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