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Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network

Author(s):

HuanHuan Cao, YuHang Zhang, Jia Zhao, Liucun Zhu, Yi Wang, JiaRui Li, Yuanming Feng and Ning Zhang   Pages 1 - 9 ( 9 )

Abstract:


Ebola hemorrhagic fever (EHF) is caused by Ebola virus (EBOV). It is reported that human could be infected by EBOV with a high fatality rate. However, association factors between EBOV and host still tend to be ambiguous. According to the “guilt by association” (GBA) principle, proteins interacting with each other are very likely to function similarly or the same. Based on this assumption, we tried to obtain EBOV infection-related human genes in a protein-protein interaction network using Dijkstra algorithm. We hope it could contribute to the discovery of novel effective treatments. Finally, 15 genes were selected as potential EBOV infection-related human genes.

Keywords:

Ebola virus, Pathogenic mechanism, The shortest path, Human protein identification, Betweenness, GO Enrichment

Affiliation:

Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement - Tianjin University Tianjin, Institute of Health Sciences, Shanghai Institutes for Biological Sciences - Chinese Academy of Sciences Shanghai, Biomedical Research Center - CODBIO Company Ltd. Tianjin, School of Life Science - Shanghai University Shanghai, School of Life Science - Shanghai University Shanghai, School of Life Science - Shanghai University Shanghai, Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement - Tianjin University Tianjin, Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement - Tianjin University Tianjin



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