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Fe3O4@SiO2@KIT-6 as an Efficient and Reusable Catalyst for the Synthesis of Novel Derivatives of 3,3'-((Aryl-1-phenyl-1H-pyrazol-4- yl)methylene)bis (1H-indole)


Mohammad Nikpassand, Leila Zare Fekri and Mozhdeh Nabatzadeh   Pages 1 - 6 ( 6 )


Korea advanced institute of science and technology cubic ordered mesoporous silica (KIT-6 mesoporous) silica coated magnetite nanoparticles, is an effective, eco-benign and recyclable catalyst for the electrophilic substitution reactions of indoles with various synthetized aldehydes to afford the corresponding novel diindolylmethanes in high yields and short reaction times. The catalyst can be recovered and reused without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification. The present methodology offers several advantages such as aqueous media, excellent yields, simple procedure, mild conditions and reduced environmental consequences. All of synthesized compounds are new and were characterized by IR, NMR and elemental analyses.


Fe3O4@SiO2@KIT-6, diindolylmethane, Indole, Room temperature.


Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht

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