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Design, Synthesis and hMAO Inhibitory Screening of Novel 2-Pyrazoline Analogues

Author(s):

Begüm Evranos Aksöz, Gülberk Uçar and Kemal Yelekçi   Pages 1 - 11 ( 11 )

Abstract:


A series of 3,5-diaryl-2-pyrazoline derivatives was synthesized via the reaction of various chalcones with hydrazide compounds in ethanol. Structural elucidation of the compounds was performed by IR, 1H NMR, 13C NMR, mass spectral data, and elemental analyses. The new compounds were tested for their human monoamine oxidase (hMAO) inhibitory activities. All compounds were found to be competitive, reversible, and selective inhibitors for hMAO-A. Compounds 5a, 5b, 5f, 5h, 5i and 5l showed higher selectivity towards hMAO than moclobemide, the known selective and competitive hMAO-A inhibitor. Compounds 5c, 5d, 5i and 5l exhibited also higher inhibitory potency towards hMAO-A than moclobemide. The AutoDock 4.2 program was employed to perform automated molecular docking. The calculated results obtained computationally were in good agreement with the experimental values.

Keywords:

2-Pyrazoline, Molecular docking, AutoDock 4.2, Human MAO, Inhibition, Synthesis

Affiliation:

Medicines and Medical Devices Agency, Analyses and Control Laboratories, 06100 Sıhhıye, Ankara, Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhiye, Ankara, Faculty of Engineering and Natural Sciences, Department of Bioinformatics and Genetics (Head) Cibali Campus, Kadir Has University, 34083 Fatih, İstanbul



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