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Caffeic Acid in Dermatological Formulations: In Vitro Release Profile and Skin Absorption

Author(s):

Caroline Magnani Spagnol , Leonardo Delello Di Filippo, Vera Lucia Borges Isaac , Marcos Antonio Corrêa and Hérida Regina Nunes Salgado   Pages 1 - 7 ( 7 )

Abstract:


Caffeic acid (CA) is a cinnamic acid derivative, found in many vegetable products, with powerful antioxidant activity, the ability to increase collagen production and capacity to prevent premature aging of the skin. The classic emulsions of CA are widely used by the consumer to provide a pleasant, refreshing sensorial experience; however, preparations developed in the form of dry film are presented as a technological alternative due to its facile and safe transportation. The aim of this study was to evaluate the release, permeation, and retention of CA in a film and emulsion through in vitro experiments. The release evaluation of CA from the emulsion and the film was performed using modified Franz diffusion cells, with an area of 1.77 cm², using Microette equipment (Hanson Research) with a cellulose membrane. The evaluation of the permeation of CA from the formulations was conducted using a similar technique of release, except that a biological membrane was used. High release of active compound and reduced permeation was observed, indicating that CA was able to be retained in the epidermis/dermis, where it should have the desired action. The concentration of caffeic acid in the skin was higher for the film formulation than for the emulsion. This demonstrates a greater efficiency of this type of innovative release system, besides its facile and safe transportation. Keyword: The caffeic acid (CA) is a cinnamic acid derivative, found in a lot of vegetable products with powerful antioxidant activity, increasing collagen production and preventing premature aging of the skin. The classic emulsions are widely used by the consumer by providing pleasant refreshing sensorial, however, preparations developed in the form of dry film are presented as a technological alternative for its ease and safety in transportation. The aim of this study was to evaluate the release, permeation and retention of CA in a film and an emulsion through in vitro experiments. The release evaluation of caffeic acid from the emulsion and the film was performed using modified Franz diffusion cells with an area of 1.77 cm² using Microette equipment (Hanson Research) with cellulose membrane. The evaluation of the permeation of CA from the formulations was conducted using a similar technique of the release, however, a biological membrane was used. It was observed high release of active compound and reduced permeation, indicating that it was able to remain retained in the epidermis/dermis, where it should have action.

Keywords:

caffeic acid, dermatological formulations, antioxidant, release, permeation, retention, in vitro experiments.

Affiliation:

Department of Drugs and Medicines, Faculty of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista “Júlio de Mesquita Filho”-UNESP, Araraquara, São Paulo, Department of Drugs and Medicines, Faculty of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista “Júlio de Mesquita Filho”-NESP, Araraquara, São Paulo, Department of Drugs and Medicines, Faculty of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista “Júlio de Mesquita Filho”-UNESP, Araraquara, São Paulo, Department of Drugs and Medicines, Faculty of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista “Júlio de Mesquita Filho”-UNESP, Araraquara, São Paulo, Department of Drugs and Medicines, Faculty of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista “Júlio de Mesquita Filho”-UNESP, Araraquara, São Paulo



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