Ashraf Sadat Shahvelayati*, Maryam Ghazvini, Khadijeh Yadollahzadeh and Akram Sadat Delbari Pages 1 - 5 ( 5 )
Background: The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. In recent years, the use of ionic liquids as a green media for organic synthesis has become a chief study area. This is due to their unique properties such as non-volatility, non-flammability, chemical and thermal stability, immiscibility with both organic compounds and water and recyclability. Ionic liquids are used as environmentally friendly solvents instead of hazardous organic solvents.
Objective: we report the condensation reaction between α-oximinoketone and dialkyl acetylene dicarboxylate in the presence of triphenylphosphine to afford substituted pyrroles under ionic liquid conditions in good yields.
Result: Densely functionalized pyrroles was easily prepared from reaction of α-oximinoketones, dialkyl acetylene dicarboxylate in the presence of triphenylphosphine in a quantitative yield under ionic liquid conditions at room temperature (Scheme 1).
Conclusion: In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time, having easily available-recyclable ionic liquids, and good to high yields are advantages of present method.
Dialkyl acetylenedicarboxylate, α-Oximinoketone, N-Hydroxypyrroles, Ionic liquid, Tandem reaction.
Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Department of Chemistry, Payame Noor University, P.O. Box: 19395-4697, Tehran, Department of Chemistry, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Department of Chemistry, College of Science, Islamshahr Branch, Islamic Azad University, Tehran