Fawzi Mahomoodally* and Shanoo Suroowan
Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse. It was found that Indeed, herbal products can act on multiple targets involved in the pathogenesis of CAIDs. Curcumin, quercetin, naringenin, and hesperentin can nullify the damaging effects of reactive oxygen species (ROS). Periplocoside A, oroxylin A, and celastrol can redress the imbalance between T helper 17 and T regulatory cells and suppress inflammation. Moreover, berberine and salvianolic acid B have demonstrated action like conventional non-steroidal anti-inflammatory drugs and inhibit the cyclooxygenase-2 enzymes. Mentha spicata oil causes analgesia and decreases pain. , Boswellia serrata Roxb. ex Colebr., avocado-soyabean unsaponifiables, arnica, and comfrey gel extract can improve pain and physical function in patients suffering from osteoarthritis and other CAIDs. Novel therapeutic approaches involve the use of nanoparticles loaded with Zingiber officinale Roscoe extracts to specifically target the colon in irritable bowel disease. In silico approaches remain also a pertinent avenue to unveil highly compatible herbal metabolites binding multiple targets involved in inflammation.
Auto-inflammatory disorders, ethnobotany, herbal products, irritable bowel disease, osteoarthritis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus
Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Reduit, Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Reduit