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Synthesis and Antifungal Activities of Drimane-Amide Derivatives from Sclareol

Author(s):

Miaofeng Ma, Jili Feng, Dezhi Wang, Shu-Wei Chen and Hui Xu*   Pages 1 - 9 ( 9 )

Abstract:


By using sclareol as a lead compound, 23 drimane-amide derivatives were designed, synthesized, and preliminarily evaluated for their antifungal activities in vitro by using the mycelium growth rate method. Among them, compound A3 showed the most potent activities with IC50 values of 3.36 and 3.18 μg/mL against Botrytis cinerea and Glomerella cingulata, respectively. The structure-activity relationship studies of compounds A1-10 indicated that both the position and type of substituent on the phenyl ring had significant effects on their antifungal activities.

Keywords:

Sclareol, drimane-amide derivative, synthesis, phytopathogenic fungi, antifungal activity, structure-activity relationship

Affiliation:

College of Chemistry and Pharmacy, Northwest A&F University; Yangling, Shaanxi 712100, College of Life Science, Northwest A&F University; Yangling, Shaanxi 712100, College of Chemistry and Pharmacy, Northwest A&F University; Yangling, Shaanxi 712100, College of Chemistry and Pharmacy, Northwest A&F University; Yangling, Shaanxi 712100, College of Chemistry and Pharmacy, Northwest A&F University; Yangling, Shaanxi 712100



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