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Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients

Author(s):

Halit Halil*, Nilden Tuygun, Erhan Aksoy, Ozcan Erel and Can Demir Karacan   Pages 1 - 4 ( 4 )

Abstract:


Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body

Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients.

Methods: Ninety patients, 54 epilepsy and 36 control were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide / native, disulfide / total thiol and native thiol/ total thiol ratios were calculated. Hence, the ratios of disulfide/ native thiol, disulfide / total thiol and native thiol/ total thiol were calculated.

Results: Serum levels of native thiol, total thiol and disulfide were significantly lower in the epilepsy group than the control group. The ratio of disulfide / native thiol and disulfide / total thiol were significantly higher in the study group than the control group. As well as, the native thiol / total thiol ratio was lower in the epilepsy group than the control group. Native thiol, total thiol and disulfide were significantly lower in the epilepsy group who were taking anti-epileptic drugs than those who were not taking anti-epileptic drugs.

Conclusion: We demonstrated a meaningful relationship between oxidative stress markers and epilepsy in pediatric patients.

Keywords:

Biomarkers, disulfide, epilepsy, pediatrics, thiol, oxidative stress.

Affiliation:

Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Department of Pediatric Neurology, Yıldırım Beyazit University, Ankara, Department of Biochemistry, Yıldırım Beyazit University, Ankara, Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital



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