Jihong An* Pages 1 - 5 ( 5 )
Aim and Objective: This study aims to investigate the expression and clinical significance of Th17 cells and related factors in peripheral blood of patients with autoimmune hepatitis (AIH).Materials and Methods: A retrospective selection of 100 patients with AIH were included as study group, and 100 healthy volunteers in the outpatient clinic were selected as the control group. The levels of IL-17, IL-6, IL-21 and TNF-α in peripheral blood of all subjects were detected by enzyme-linked immunosorbent assay and the frequency of Th17 cells and Treg cells was detected by flow cytometry. Results: Results showed that the study group had higher levels of serum total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyltranspeptidase (γ-GT), immunoglobulin G (IgG), immunoglobulin M (IgM), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) than control group, as well as higher levels of IL-17, IL-6, IL-21 and TNF-α in serum. The frequency of Th17 cells in peripheral blood was higher in study group while the frequency of Treg cells was lower. Also, serum IL-17, TNF-α levels and Th17 cells frequency were positively correlated with ALT and AST, whereas Treg cells frequency were negatively correlated with ALT and AST levels. Conclusion: Our finding demonstrates that Th17 cell frequency and their related factors IL-17 and TNF-α, are associated with liver damage, which might be used to monitor AIH disease severity.
Th17 cells, IL-17, TNF-α, autoimmune hepatitis, liver damage, Asia-pacific region.
Department of Infectious Diseases, Inner Mongolia People's Hospital, Inner Mongolia 010017