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How Do Contrast Agents Affect Cardiac Markers and Coagulation Tests? Experimental Study

[ Vol. 22 , Issue. 5 ]

Author(s):

Mustafa Begenc Tascanov and Ataman Gönel*   Pages 355 - 360 ( 6 )

Abstract:


Background: The discovery that biotin interferes with results of troponin and Nt-proBNP led some commercial firms to update their measurement methods. In particular, the clinical incompatibility of cardiac test results may affect the risk of morbidity and mortality.

Objective: The aim of this study is to investigate the interference effects of 7 different contrast agents on cardiac markers (Troponin-I, Nt-proBNP, Mass CK-MB, CK, AST, LDH) and in coagulation tests (PT, APTT).

Methods: Seven different contrast media were added into control materials by using interference protocol. The concentrations of PT, APTT, CK, AST, LDH, Mass CK-MB, Troponin-I, and Nt-proBNP were measured by Sysmex CS-2100, Abbott c16000, Siemens Centaur XP and AFİAS-6 analyzer. The number of deviations from target values was calculated.

Results: The 7 different contrast media caused negative interference in troponin levels between 57.43% and 62.87%. It was found that different contrast media produced false negativity in the Nt-proBNP test, ranging from 6.11% to 96.01%. Enzymes and coagulation tests were less affected.

Conclusion: Different contrast media may cause false negatives in cTnI and Nt-proBNP. The contrast medium that causes the least interference should be preferred. The results of samples taken in the first hour after contrast imaging should be interpreted with care.

Keywords:

Contrast media, troponin, Nt-proBNP, interference, cardiac markers, coagulation test.

Affiliation:

Department of Cardiology, Harran University, Sanliurfa, Department of Medical Biochemistry, Harran University, Sanliurfa



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