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Three Differentially Expressed miRNAs as Potential Biomarkers for Lung Adenocarcinoma Prognosis

Author(s):

Wei Wang, Bin Liu, Xiaoran Duan, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Qiao Zhang, Feifei Feng, Yongjun Wu, Wu Yao, Qi Wang and Yongli Yang*   Pages 1 - 9 ( 9 )

Abstract:


Objective: The aim of this study is to screen MicroRNA (miRNA) related to the prognosis of lung adenocarcinoma (LUAD) and to explore the possible molecular mechanism.

Methods: A total of 535 LUAD data were downloaded from The Cancer Genome Atlas (TCGA) database. The miRNAs for LUAD prognosis were screened by Cox risk proportional regression model and Last Absolute Shrinkage and Selection Operator (LASSO) regression model. The performance of the model was verified by time-dependent Receiver Operating Characteristic (ROC) curve. The possible biological process of miRNAs’ target genes was analyzed by Gene Ontology (GO), Kyoto gene and genome encyclopedia (KEGG).

Results: 127 differentially expressed miRNAs were screened with 111 up-regulated and 16 down-regulated miRNAs. Three key miRNAs, hsa-miR-1293, hsa-miR-490 and hsa-miR-5571, were screened from survival analysis, which are significantly enriched in systemic lupus erythematosus pathways.

Conclusion: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be used as novel biomarkers for the prediction of prognosis of LUAD.

Keywords:

Lung adenocarcinoma, miRNAs, TCGA, Prognosis, Biomarkers, Screening

Affiliation:

Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou, Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou



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