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A Recent Look into Natural Products that Have Potential to Inhibit Cholinesterases and Monoamine Oxidase B: Update for 2010-2019

Author(s):

Hayrettin Ozan Gulcan and Ilkay Erdogan Orhan*   Pages 1 - 15 ( 15 )

Abstract:


With respect to the unknowns of the pathophysiology of Alzheimer’s Disease (AD)-, and Parkinson’s Disease (PD)-like neurodegenerative disorders, natural product research is still one of the valid tools in order to provide alternative and/or better treatment options. At one hand, various extracts of herbals provide a combination of actions targeting multiple receptors, on the other hand, the discovery of active natural products (i.e., secondary metabolites) generally offer alternative chemical structures either ready to be employed in clinical studies or available to be utilized as important scaffolds for the design of novel agents. Regarding the importance of the enzymes, e.g. cholinesterase and monoamine oxidase B, for the treatment of AD and PD, we have surveyed the natural product research in the last decade on this area. Particularly novel natural agents discovered within this period concomitant to novel biological activities displayed for known natural products are harmonized within the present study.

Keywords:

Acetylcholinesterase, Butyrylcholinesterase, Monoamine oxidase B, Alzheimer’s Disease, Parkinson’s Disease, Natural products

Affiliation:

Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, TR. North Cyprus, via Mersin 10, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06300



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