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Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis

[ Vol. 23 , Issue. 3 ]

Author(s):

Mutlu U. Yazıcı*, Ganime Ayar, Semra Çetinkaya, Meliksah Keskin, Ebru Azapağası, Saim Neşelioğlu, Özcan Erel and Benan Bayrakçı   Pages 185 - 190 ( 6 )

Abstract:


Aims and Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus.

Materials and Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis parameters were measured using a novel automated measurement method and the correlation between demographic data and parameters was measured.

Results: Pediatric patients were found to have low native thiols, total thiols and disulfide levels with type 1 diabetes after DKA (331.82±106.40, 362.71±113.31, 17.02±5.33 μmol/L, respectively) as compared to the control group (445.08±24.41, 481.21± 28.47, 18.06±5.12 μmol/L, respectively).

Conclusion: Thiol/disulfide homeostasis was distorted in pediatric patients with DKA. Furthermore, it was found that they are not likely to return to normal, immediately after treatment.

Keywords:

Thiol/disulfide homeostasis, diabetic ketoacidosis, type 1 diabetes mellitus, children, hyperglycemia, hyperketonemia.

Affiliation:

Department of Pediatrics, University of Health Sciences, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Department of Pediatrics, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Ankara, Department of Pediatric, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Endocrinology and Adolescent Clinic, Ankara, Department of Pediatric, University of Health Sciences, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Endocrinology and Adolescent Clinic, Ankara, Department of Pediatrics, University of Health Sciences, Pediatric Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Department of Biochemistry, University of Yildirim Beyazit, Ankara Atatürk Training and Research Hospital, Ankara, Department of Biochemistry, University of Yildirim Beyazit, Ankara Atatürk Training and Research Hospital, Ankara, Department of Pediatrics, University of Hacettepe, Pediatric Intensive Care Unit, İhsan Doğramacı Children Hospital, Ankara



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