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Identification of 2’-O-methylation site by Investigating Multi-feature Extracting Techniques

Author(s):

Qin-Lai Huang, Lida Wang, Shu-Guang Han and Hua Tang*   Pages 1 - 9 ( 9 )

Abstract:


Background: RNA methylation is a reversible post-transcriptional modification involving numerous biological processes. Ribose 2'-O-methylation is part of RNA methylation. It has shown that ribose 2'- O-methylation plays an important role in immune recognition and other pathogenesis.

Objective: We aim to design a computational method to identify2'-O-methylation.

Method: Different from the experimental method, we propose a computational workflow identifying the methylation site based on the multi-feature extracting algorithm.

Results: With a voting procedure based on 7 best feature-classifier combinations, we achieved AUC of 0.80 in 10-fold cross-validation. Furthermore, we optimized features and input the optimized features into SVM. As a results, the AUC reached to 0.813.

Conclusion: The RNA sample, especially the negative samples, used in this study are more objective and strict, so we got more representative result than state-of-arts studies.

Identification, of, 2’-O-methylation, site, by, Investigating, Multi-feature, Extracting, Techniques

Affiliation:

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Scientific Research Department, Heilongjiang Agricutural Recalmation General Hospital, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Department of Pathophysiology, Southwest Medical University, Luzhou 646000



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