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Transcription/Expression of KLRB1 Gene as A Prognostic Indicator in Human Esophageal Squamous Cell Carcinoma

Author(s):

Guangwei Zhang, Ying Liu, Fajin Dong and Xianming Liu*   Pages 1 - 15 ( 15 )

Abstract:


Aim and Objective: Esophageal squamous cell carcinoma (ESCC) is a cancer with worldwide distribution and dismal prognosis despite ongoing efforts to improve treatment options. Therefore, it is essential to identify the prognostic factors for ESCC.

Methods and Results: We determined KLRB1 to be a prognostic indicator of human ESCC. KLRB1 was expressed at low levels in ESCC patients. Based on the risk score, patients were divided into high or low risk groups. High risk patients showed a poor survival rate. The prediction model based on N stage, sex, and KLRB1 was significantly better than that based on N stage and sex. The modified prediction model showed a robust ROC curve with an AUC value of 0.973. Knockdown of KLRB1 inhibited the growth of human ESCC cells. KLRB1 regulated Akt, mTOR, p27, p38, NF-κB, Cyclin D1, and JNK signaling which was consistent with the result of GSEA.

Conclusion: KLRB1 is a potential prognostic marker for human ESCC patients.

Keywords:

ESCC, prognosis, survival, prediction model, KLRB1, treatment.

Affiliation:

The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong



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