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Flaxseed for Health and Disease: Review of Clinical Trials


Mersedeh Shayan, Safa Kamalian, Amirhossein Sahebkar* and Zahra Tayarani Najaran   Pages 1 - 24 ( 24 )


Background: Flaxseed (Linum usitatissimum) is an oil-based seed which contains high amounts of alpha-linoleic acid, linoleic acid, lignans, fiber and many other bioactive components which is suggested for healthier life. Nowadays flaxseed is known as a remarkable functional food with different health benefits for humans and protects against cardiovascular disease, diabetes, dyslipidemia, obesity and altogether metabolic syndrome.

Objectives and Methods: To review the bioactive components of flaxseed and their potential health effects, PubMed and Scopus were searched from commencement to July 2019. Keywords including: "flaxseed", "Linum usitatissimum", "metabolic syndrome", "obesity", "inflammation", "insulin resistance", "diabetes", "hyperlipidemia" and "menopause" were searched in the databases with varying combinations.

Conclusions: Consumption of flaxseed in different forms has valuable effect and protects against cardiovascular disease, hypertension, diabetes, dyslipidemia, inflammation and some other complications. Flaxseed can serve as a promising candidate for management of metabolic syndrome to control blood lipid levels, fasting blood sugar, insulin resistance, body weight, waist circumference, body mass and blood pressure.


Flaxseed, Linum usitatissimum, Metabolic syndrome, Inflammation, Cardiovascular disease, Menopause.


Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Departments of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Halal Research Center of IRI, FDA, Tehran, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad

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