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Phytochemical Analysis and Antidiabetic Potential of Armoracia Rusticana: Pharmacological and Computational Approach

Author(s):

Anam Javaid, Usman Ali Ashfaq*, Zeeshan Zafar, Arina Akmal, Saman Taj and Hina Khalid   Pages 1 - 7 ( 7 )

Abstract:


Aims & Objective: Armoracia Rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia Rusticana.

Methods: The antidiabetic analysis revealed Armoracia Rusticana was highly active against α-glucosidase with IC50 values of 5.6 µg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug.

Results: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-O-beta-D-xylopyranoside which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties which further strengthen its validation.

Conclusion: It was, therefore, concluded that Armoracia Rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus.

Keywords:

Anti-diabetic, Phytochemicals, Docking

Affiliation:

Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Department of Bioinformatics and Biotechnology, Government College University, Faisalabad



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