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Design and Synthesis of an Aniline Derivative with Biological Activity on Heart Failure

Author(s):

Garcimarero-Espino E. Alejandra, Figueroa-Valverde Lauro*, Rosas-Nexticapa Marcela, Lopez-Ramos Maria, Diaz Cedillo Francisco, Mateu-Armand Virginia and Ortiz-Ake Yazmin   Pages 1 - 12 ( 12 )

Abstract:


Background: Several compounds have been synthesized as a therapeutic alternative for heart failure; however, its preparation requires special conditions.

Objective: The aim of this study, was to synthesize some aniline derivatives (4-9) from 3-ethynylaniline to evaluate their biological activity against heart failure.

Methods: The synthesis of aniline derivatives involved a series of reactions such as etherification, addition, and cyclization. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods. In addition, to evaluate the biological activity of compounds an ischemia/reperfusion injury model was used.

Results: The results showed that compound 8 decreases heart failure, which translates into a decrease in the infarction area compared to compounds 4-7 and 9.

Conclusion: This study is reported a facile method for the preparation of aniline derivatives. This method offers some advantages such as; a simple procedure, low cost, and ease of work. In addition, compound 8 showed an interesting biological activity against heart failure. This phenomenon is particularly interesting because the biological activity induced by this compound could involve a molecular mechanism different compared with other drugs used for the treatment of heart failure.

Keywords:

Synthesis, aniline, derivatives, etherification, heart failure, biological activity

Affiliation:

Facultad de Medicina, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche, Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz, Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche



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