Submit Manuscript  

Article Details

Green Synthesis of Thiazole Derivatives using Multi-Component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activity


Naghmeh Faal Hamedani*, Leila Azad, Shahin Shafiee and Annataj Noushin   Pages 1 - 10 ( 10 )


Aims & Objective: In this work, multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in water at 100oC was investigated.

Materials and Methods: In these reactions, thiazole derivatives produce in good to excellent yields and short time. Also, antioxidant activity was studied for the some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and comparing results with synthetic antioxidants (TBHQ and BHT).

Results: As a result, compounds 4b show excellent DPPH radical trapping and reducing strength of ferric ion. These compounds have biological potential because of thiazole core. For this reason, the antimicrobial activity of some synthesized compounds was studied by employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria.

Conclusion: The results of disk diffusion test showed that these compounds prevented the bacterial growth.


Alkyl bromides, Aldehyde, Multicomponent reactions, Ammonium acetate, Sodium cyanide, KF/Clinoptilolite nanoparticles.


Department of Chemistry, Faculty of Valiasr, Tehran Branch, Technical and Vocational University (TVU), Tehran, Department of Chemistry, Khodabandeh Branch, Islamic Azad University, Khodabandeh, Danayan Fara Kimiya (DFK)company, Gheysar Aminpour Blv., Shahin Shahr, Isfahan, Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan

Read Full-Text article