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ZnO-nanocatalyst Promoted the Production of Imidazole Derivatives via four-component Reaction of Aminoacid: Study of Antioxidant and Antimicrobial Activity


Maryam Ghazvini*, Fatemeh Sheikholeslami-Farahani, Shahin Shafiee, Masoomeh Salimifard and Ali Akbar Eslami   Pages 1 - 9 ( 9 )


Aim and Objective: In current research, imidazole derivatives are synthesized via a new process of four component reaction of trichloroacetonitrile, amides, alkyl bromides and amino acids catalyzed by zinc oxide nanoparticles (ZnO-NPs) as a simple and recyclable catalyst in water at room temperature. Among investigated compounds, compounds 5b have good results relative to butylated hydroxytoluene (BHT) and 2-tert-butylhydroquinone (TBHQ) as standard antioxidant. The achieved outcomes of disk diffusion experiment showed that these compounds avoided the growth of bacterial.

Materials and Methods: In this research, all chemicals are purchased from Fluka (Buchs, Switzerland) and employed with any purification. For measuring infrared spectroscopy and melting point, a Shimadzu IR-460 spectrometer and Electrothermal 9100 apparatus are utilized respectively. BRUKER DRX-400 AVANCE spectrometer is used for giving the 1H, and 13C-NMR spectra at 400.1 and 100 MHz respectively. For recording mass spectra, A FINNIGAN-MAT 8430 spectrometer with an ionization potential of 70 eV was utilized. The scanning electron microscopy (SEM) employing a Holland Philips XL30 microscope was used for determination of ZnO nanocomposites morphology. X-ray diffraction (XRD) analysis at room temperature using a Holland Philips Xpert X-ray powder diffractometer, with CuK


Alkyl bromides, Aminoacides, Multicomponent reactions, imidazole, zinc oxide nanoparticles (ZnO-NPs).


Department of Chemistry, Payame Noor university, P. O Box:3971189451, Tehran,, Department of Chemistry, Firoozkooh Branch, Islamic Azad University, Firoozkooh,, Danayan Fara Kimiya (DFK)company, Gheysar Aminpour Blv., Shahin Shahr, Isfahan,, Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr,, Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr

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