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FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data

Author(s):

Ying Lu*, Jing Shao, Xu Shu, Yaofei Jiang, Jianfang Rong, Yongkang Lai and Ji Liu   Pages 1 - 8 ( 8 )

Abstract:


Aim and Objective: Fatty acid desaturase 1 (FADS1) has been reported to be a potential biomarker in various cancers. However, no study has explored the relationship between FADS1 expression and bladder cancer. Our study aimed to investigate the role of FADS1 in bladder cancer prognosis via The Cancer Genome Atlas (TCGA).

Materials and Methods: RNA-Seq expression of 414 tumor tissues and 19 paired normal tissues, as well as corresponding clinical data, were downloaded from TCGA database. Two cancer cases were excluded due to a lack of clinical information. The association between FADS1 and the clinicopathological features of bladder cancer was analyzed. This study was conducted in October of 2019 in China.

Results: The high expression of FADS1 in bladder cancer was significantly related to histological grade (OR = 0.155 for low vs. high), clinical stage (OR=2.074 for III or IV vs. I or II), T classification (OR=2.326 for T3 or T4 vs. T1 or T2), lymphatic metastasis (OR=1.923 for N1 or N2 or N3 vs. N0) and distant metastasis (OR=4.883 for yes vs. no) (all p-values <0.05). Bladder cancer with high FADS1 levels was related to a worse prognosis than bladder cancer with low FADS1 levels (p= 1.626*10-5 ), according to median expression value 3.622. FADS1 was an independent factor of overall survival in bladder cancer, with a hazard ratio of 1.048 (95%CI: 1.020–1.077, p = 0.001).

Conclusions: Increased FADS1 expression in bladder cancer is associated with advanced clinical pathological features and may be a potential biomarker for poor prognosis.

Keywords:

FADS1, Bladder cancer, Poor prognosis, Biomarker, TCGA, Survival

Affiliation:

Department of Gastroenterology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, Department of Urology, First Affiliated Hospital of Nanchang University, NO. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province



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