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The Pattern of Calculated Inflammation Ratios as Prognostic Values in Patients with Colorectal Cancer

Author(s):

Andra Ciocan, Sorana D. Bolboacă*, Cristina Drugan, Răzvan A. Ciocan, Florin Graur and Nadim AL Hajjar   Pages 1 - 8 ( 8 )

Abstract:


Aim: In our study, we evaluated the prognostic value of four calculated inflammatory ratios in patients with colorectal cancer.

Material and methods: A six years retrospective study was conducted on subjects admitted for colorectal cancer at "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania, from January 2014 until September 2019. The medical charts of patients diagnosed with colorectal cancer were used as the source of raw data and for the calculation of four ratios (neutrophil-to-lymphocyte ratio-NLR, derived neutrophil-to-lymphocyte ratio-dNLR, platelet-to-lymphocyte ratio-PLR, and systemic immune-inflammation index-SII), considered as prognostic markers related to mortality in colorectal cancer.

Results: One thousand six hundred and eighty-eight patients, with ages ranging from 17 to 98 years, were evaluated. NLR and dNLR displayed significantly higher values among patients who died (NLR: 4.2 for deceased vs. 3.4 for alive, Pvalue=0.0224; dNLR: 2.7 for deceased vs. 2.3 for alive, P-value=0.0566). Ischemic cardiomyopathy (odds ratio (OR)=2.70), liver cirrhosis (OR=7.84), postoperative complications (OR=2.39), and neutrophil-to-lymphocyte ratio (OR=1.08) proved to be significant prognostic factors for the primary outcome, independent of age and gender.

Conclusions: Patients with high NLR, postoperative complications, ischemic cardiomyopathy an d/or liver cirrhosis are the candidates to a less favorable outcome among subjects with colorectal cancer regardless the age and gender.

Keywords:

inflammation ratios, colorectal cancer, prognostic factors.

Affiliation:

Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy ClujNapoca, Louis Pasteur Street, No. 6, 400349 Cluj-Napoc, Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy ClujNapoca, Louis Pasteur Street, No. 6, 400349 Cluj-Napoc, Department of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Street, No. 6, 400349 Cluj-Napoc, Department of Practical Skills – Humanities Sciences, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Marinescu Street, No. 23, 400337 Cluj-Napoc, 3rd Department of Surgery, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Street, No. 19-21, 400162 Cluj-Napoc, 3rd Department of Surgery, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Croitorilor Street, No. 19-21, 400162 Cluj-Napoc



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