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Molecular Mechanisms of Thymoquinone as Anticancer agent

Author(s):

Fatma Ismail Alhmied, Ali Hassan Alammar, Bayan Mohammed Alsultan, Marooj Alshehri and Faheem Hyder Pottoo*   Pages 1 - 11 ( 11 )

Abstract:


Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and down regulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27and p21 a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induced G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anti-cancer properties of thymoquinone.

Keywords:

Thymoquinone, Nigella Sativa, Angiogenesis, Metastasis, Invasion, Cell Cycle, Inflammation, Oxidative Stress

Affiliation:

College of Medicine, Imam Abdulrahman Bin Faisal University, P.O BOX 1982, Dammam 31441, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O BOX 1982, Dammam 31441, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O BOX 1982, Dammam 31441, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O BOX 1982, Dammam 31441, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O BOX 1982, Dammam 31441



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