Submit Manuscript  

Article Details


Thiol/Disulfide Homeostasis as an Early Biomarker to Differentiate Sepsis from Pneumonia in Intensive Care Units

Author(s):

Esra Cakir*, Gamze Gok, Ozcan Erel and Isil Ozkocak Turan   Pages 1 - 8 ( 8 )

Abstract:


Background: It is possible that patients with pneumonia also may have sepsis and the separation of these two clinical entities may induce some trouble to clinicians

Objective: In order to separate a patient with pneumonia and a patient with sepsis, we qualify thiol/disulfide homeostasis as a potential biomarker.

Method: This study designed between February 2018 – February 2019 prospectively. All patients in the intensive care unit with pneumonia and sepsis were enrolled in the study. At the time of hospitalization, thiol/disulfide homeostasis was measured. Patients diagnosed with sepsis and pneumonia were compared, in regards to thiol/disulfide homeostasis.

Results: During research period, 103 patients with sepsis and 120 patients with pneumonia were enrolled into the study. When we compared native-thiol, total-thiol, and disulfide levels in both sepsis and pneumonia patients, we had similar results (p>0.05). In sepsis group, index-1 (disulfide/native thiol ratio) and index-2 (disulfide/total thiol ratio) were found out to be statistically higher than the pneumonia group, and index-3 (native thiol/total thiol ratio) was statistically lower than the pneumonia group (p=0.020, p= 0.021, p=0.021, respectively).

Conclusion: In this study, we showed that thiol/disulfide homeostasis can be used as new markers in the early period in order to separate patients with sepsis and patients with pneumonia.

Keywords:

Thiol/disulfide homeostasis, sepsis, pneumonia, intensive care unit

Affiliation:

Department of Anesthesiology and Clinical of Critical Care, Health Sciences University, Ankara Numune Education and Research Hospital, Ankara, Department of Anesthesiology and Clinical of Critical Care, Health Sciences University, Ankara Numune Education and Research Hospital, Ankara, Department of Biochemistry, Ankara Yıldırım Beyazit University, Ankara, Department of Anesthesiology and Clinical of Critical Care, Health Sciences University, Ankara Numune Education and Research Hospital, Ankara



Read Full-Text article