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Serum Pro-oxidant-Antioxidant Balance in subjects with Type 2 Diabetes Mellitus

Author(s):

Mahsa Ahmadnezhad, Hamideh Ghazizadeh, Moniba Bijari, Mohammad Reza Oladi, Habibollah Esmaily, Seyed Javad Hoseini, Elham Barati, Samaneh Silakhori, Maryam Moham-madi-Bajgiran, Hafezeh Davari, Mohammad Reza Parizadeh, Naghme Mokhber, Payam Sharifan, Seyed Rafie Aref- Hosseini, Gordon A Ferns, Mohsen Moohebati and Majid Ghayour-Mobarhan*   Pages 1 - 7 ( 7 )

Abstract:


Aim and Objective: Diabetes mellitus is associated with inflammation and increased oxidative stress. In the current study, we aimed to investigate the relationship between type 2 diabetes mellitus (T2DM) and serum pro-oxidantantioxidant balance (PAB) in a large population-based study.

Methods: In this cross-sectional study, 7888 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Participants were divided into three groups, based on their serum PAB values (levels < 36.4, 36.4-82.6 and > 82.6 HK). Serum PAB values were measured using a colorimetric method and enzyme-linked immune sorbent assay (ELISA).

Results: Serum PAB in subjects with and without diabetes was reported 76.85 ± 61.07 HK and 69.51 ± 55.50 HK. In subjects with a serum PAB > 82.6 HK the risk of T2DM was 1.2 fold higher in comparison to subjects with a serum PAB < 36.4 HK (OR: 1.26, 95% CI: 1.09 – 1.47, P-value: 0.002). This association remained significant after adjustment for confounding factors in multivariable analysis (OR: 1.19, 95% CI: 1.02 – 1.38, P-value: 0.027).

Conclusion: Increased pro-oxidant levels may be a major complication of T2DM in our study subjects and PAB could be an indicator of higher oxidative stress in T2DM patients from northeastern Iran.

Keywords:

Pro-oxidant-Antioxidant Balance, Type 2 Diabetes Mellitus, MASHAD cohort study, Oxidative stress, Inflammation

Affiliation:

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Student research committee, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad,, Department of Psychiatry, Faculty of Medicine & Psychiatric Research Centre, Ebn-sina Hospital, Mashad University of Medical Sciences, Mashhad,, Student research committee, Mashhad University of Medical Sciences, Mashhad,, Department of Nutrition Biochemistry, Tabriz University of Medical Sciences, Tabriz,, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH,, Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad,, International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad



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