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In-silico analysis of angiotensin converting enzyme 2 (ACE2) of livestock, pet and poultry animals to determine its susceptibility to SARS–CoV- 2 infection

Author(s):

Aman Kumar*, Anil Panwar, Kanisht Batra, Sachinandan Dey and Sushila Maan   Pages 1 - 15 ( 15 )

Abstract:


Background: Novel coronavirus SARS-CoV-2 is responsible of COVID-19 pandemic. It was first reported in Wuhan, China in December, 2019 and despite the tremendous efforts to control the disease, it has now spread almost all over the world.The interaction of SARS-CoV-2spike protein and its acceptor protein ACE2 is an important issue in determining viralhost range and cross-species infection, while the binding capacity of spike protein toACE2 of different species is unknown.

Objective: The present study has been conducted to determine the susceptibility of livestock, poultry and pets to SARSCoV-2.

Methods: We evaluated the receptor-utilizing capability of ACE2sfrom various species by sequence alignment,phylogenetic clustering and protein-ligand interaction studies with the currently knownACE2s utilized by SARS-CoV-2.

Result:In-silico study predicted that SARS-CoV-2 tends to utilize ACE2s ofvarious animal species with varied possible interactions and theprobability ofthe receptor utilization will be greater in horse and poor in chicken followed by ruminants.

Conclusion: Present studypredicted that SARS-CoV-2 tends to utilize ACE2s ofvarious livestock and poultry species with greater probability in equine and poor in chicken. Study may provide important insights into the animal models for SARSCoV-2 and animal management for COVID-19 control.

Keywords:

: COVID-19, pandemic, SARS, ACE-2, domestic animal, protein docking

Affiliation:

Department of Animal Biotechnology,LalaLajpatRai University of Veterinary and Animal Sciences (LUVAS), Hisar, Department of Molecular Biology, Biotechnology and Bioinformatics CCS Haryana Agricultural University, Hisar, Haryana, Department of Animal Biotechnology,LalaLajpatRai University of Veterinary and Animal Sciences (LUVAS), Hisar, Division of Animal Biotechnology, ICAR-NDRI Karnal,Haryana , Department of Animal Biotechnology,LalaLajpatRai University of Veterinary and Animal Sciences (LUVAS), Hisar



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