Submit Manuscript  

Article Details


Anti-Cancer and Antibacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

Author(s):

Hashem Yaghoubi*, Amin Izadpanah*, Shahla Nedaei, Hossein Akbari, Elmira Mikaeili Agah, Ricardo Mostany, Bysani Chandrasekar, Eckhard Alt and Reza Izadpanah   Pages 1 - 14 ( 14 )

Abstract:


Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic agents in cancer treatment. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient and expensive, and are fraught with toxicity.

Objective: Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using the aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we further investigated their potential as anti-cancer and antibacterial agents.

Methods: The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM and TEM. In addition, their potential to inhibit cancer cell (MCF-7 and AGS) proliferation as well as the growth of infectious bacteria were investigated. Synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy.

Results: The size of nanoparticles ranged between 20-30nm and exerted significant cytotoxicity and bactericidal effects in a concentration and time dependent manner compared to T. boudieri extract alone. Interestingly, synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.

Conclusion: This study shows that synthesis of smaller AgNPs correlated with longer synthesis time and enhanced cytotoxic and anti-bacterial effects.

Keywords:

Silver Nanoparticles, Terfezia boudieri, Cancer, Green synthesis, antibacterial

Affiliation:

Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, The Tulane University School of Medicine, New Orleans, Louisiana, Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Department of Physics, Ardabil Branch, Islamic Azad University, Ardabil, Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Department of Surgery, The Tulane University School of Medicine, New Orleans, Louisiana, Department of Medicine, University of Missouri School of Medicine and Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, The Tulane University School of Medicine, New Orleans, Louisiana, Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, The Tulane University School of Medicine, New Orleans, Louisiana



Read Full-Text article