Submit Manuscript  

Article Details


A Fusion Method Based on Alignment Software with SNP and Indel Detection Methods

Author(s):

Guobing Chen, Chao Tang, Jun Qi, Ying Wang* and Xiaolong Shi*   Pages 1 - 9 ( 9 )

Abstract:


Background: With the advent of the second generation sequencing technology, the discovery of sequence alignment and sequence variation is a long-standing challenge.

Results: A method based on general alignment software, SNP and Indel software tools was proposed in this paper. By comparing the advantages of traditional alignment software, we can produce the best alignment. SNP and Indel detection tools fusion research found that different depth of sequencing effect is different. When the sequence depth reaches a certain value, select one of the software for testing.

Conclusions: Finally, the experimental verification shows that SNP and Indel have certain advantages in the comparison of the effects of the fusion method.

Keywords:

second-generation sequencing, SNP, Indel, fusion research, software tools, sequence alignment

Affiliation:

Chongqing Key Laboratory of Spatial Data Mining and Big Data Integration for Ecology and Environment, Rongzhi College of Chongqing Technology and Business University , Chongqing 401320, Radiation & Cancer Biology Laboratory, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, Radiation & Cancer Biology Laboratory, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, Radiation & Cancer Biology Laboratory, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, Radiation & Cancer Biology Laboratory, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030



Read Full-Text article