Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem Hyder Pottoo, Javed Ali and Sanjula Baboota Pages 1 - 14 ( 14 )
Neurodegenerative disorders are result of continuous deterioration of the structure and function of neurons, involving death of neurons. Neurodegenerative disorders affect millions of people around the world. Several conventional drug delivery strategies are available to treat neurological disorders. But they are unable to provide adequate cytoarchitecture restoration and connection patterns due to lower solubility, poor bioavailability, drug resistance and incapability to traverse the blood brain barrier (BBB). Therefore, designing and developing of new and efficient delivery systems that can bring drugs to CNS and have good bioavailability in the brain is very important. Nano drug delivery system acts as a ray of hope in the diagnosis and treatment of neurological disorders. The use of nanomedicines encapsulating therapeutic molecules may enhance transport of drug across BBB, absorption of drug and its controlled release in the human body with minimum adverse effects. This review article includes a comprehensive overview on the BBB, recent developments and application of nanomedicines including liposomes, nanoparticles, nanomicelles, carbon nanotubes, etc. to the management as well as clinical therapy of various neurodegenerative disorders.
Nanomedicines, neurological disorder, nanoparticles, nanocrystals, neurodegenerative disorders, central nervous system
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, DelhiRoorkee Highway, Meerut-250005, Uttar Pradesh, Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, DelhiRoorkee Highway, Meerut-250005, Uttar Pradesh, Department of Pharmaceutics, School of Medical and Allied Sciences, K.R. Mangalam University, Gurgaon, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O.BOX 1982, Damman 31441, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi