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Virus as nanocarrier for drug delivery redefining medical therapeutics - A status report

Author(s):

Sanjay Kumar Ojha*, Ritesh Pattnaik, Puneet Kumar Singh, Shubha Dixit, Snehasish Mishra, Sreyasi Pal and Subrat Kumar*   Pages 1 - 14 ( 14 )

Abstract:


Over the last two decades, drug delivery systems have evolved at a tremendous rate. Synthetic nanoparticles have played an important role in the design of vaccine and their delivery as many of them have shown improved safety and efficacy over conventional formulations. Nanocarriers formulated by natural, biological building blocks have become an important tool in the field biomedicine. A successful nanocarrier must have certain properties like evading the host immune system, target specificity, cellular entry, escape from endosomes, and ability to release material into the cytoplasm. Some or all of these functions can be performed by viruses making them a suitable candidate for naturally occurring nanocarriers. Moreover, viruses can be made non-infectious and non-replicative without compromising their ability to penetrate cells thus making them useful for a vast spectrum of applications. Currently, various carrier molecules are under different stages of development to become bio-nano capsules. This review covers the advances made in the field of viruses as potential nanocarriers and discusses the related technologies and strategies to target specific cells by using virus inspired nanocarriers. In future, these virus-based nano-formulations will be able to provide solutions towards pressing and emerging infectious diseases.

Keywords:

Drug delivery, Synthetic nanoparticles, Nanocarrier, Virus, Bio-nano capsules, Infectious disease.

Affiliation:

Pandorum Technologies Pvt. Ltd., Bangalore Bioinnovation Centre, Helix Biotech Park, Electronic City Phase 1, Bengaluru - 560 100, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed-to-beUniversity, Bhubaneswar 751 024, Bioenergy Lab and BDTC, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed-to-be-University, Bhubaneswar 751 024, School of Pharmacy, Lloyd Institute of Management and Technology, PlotNo.11, Knowledge Park II Greater Noida- 201310, Bioenergy Lab and BDTC, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed-to-be-University, Bhubaneswar 751 024, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed-to-beUniversity, Bhubaneswar 751 024, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed-to-beUniversity, Bhubaneswar 751 024



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