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Solid Electrodes in Electroanalytical Chemistry: Present Applications and Prospects for High Throughput Screening of Drug Compounds

[ Vol. 10 , Issue. 7 ]

Author(s):

Bengi Uslu and Sibel A. Ozkan   Pages 495 - 513 ( 19 )

Abstract:


This review summarizes recent progress in the development and application of solid electrodes to the screening of pharmaceutical dosage forms and biological fluids. Recent trends and advances in the electroanalytical chemistry of solid electrodes, microelectrodes and electrochemical sensors are reviewed. The varieties of solid electrodes and their basic physico-chemical properties and some specific characteristics including some supramolecular phenomena at their surface are surveyed. This review also includes some selected designs and their applications. Despite many reviews about individual solid electrodes in the literature, this review offers the first comprehensive report on all forms of solid electrodes. Special attention is paid to the possibilities of solid electrodes in high throughput electroanalytical investigation of drug dosage forms and biological samples using modern electroanalytical techniques. Various selected studies on these subjects since 1996 are reviewed in this paper.

Keywords:

Solid electrodes, voltammetry, electroanalytical screening, drugs, biological media, supramolecular surface phenomena

Affiliation:

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Tandogan, Ankara,Turkey.



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