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Gel-Based Versus Gel-Free Proteomics: A Review

[ Vol. 8 , Issue. 8 ]

Author(s):

Geert Baggerman, Evy Vierstraete, Arnold De Loof and Liliane Schoofs   Pages 669 - 677 ( 9 )

Abstract:


With the sequencing of the genome of over 150 organisms, the field of biology has been revolutionised. Instead of studying one gene or protein at the time, it is now possible to study the effect of physiological or pathological changes on the expressioin of all genes or proteins in the organism. Proteomics aims at the simultaneous analysis of all proteins expressed by a cell, tissue or organism in a specific physiological condition. Because proteins are the effector molecules in all organsims, it is evident that changes in the physiological condition of an organism will be reflected by changes in protein expression

Keywords:

Proteomics, peptidomics, MudPit, ICAT, 2D-DIGE

Affiliation:

Laboratory ofDevelopmental Physiology, Genomics and Proteomics, K.U. Leuven,Naamsestraat 59, B-3000 Leuven, Belgium.



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