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Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

[ Vol. 8 , Issue. 3 ]

Author(s):

Tomas Ganz   Pages 209 - 217 ( 9 )

Abstract:


Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. In mammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widely distributed in various animal species and tissues. The first part of this review provides a historical overview of the ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update on mammalian defensins and their role in host defense to infections.

Keywords:

history, membrane interactions, peptide structure

Affiliation:

chs 37-055, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA90095-1690, USA.



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