Submit Manuscript  

Article Details

Natural Product-Like and Other Biologically Active Heterocyclic Libraries Using Solid-Phase Techniques in the Post-Genomic Era

[ Vol. 6 , Issue. 7 ]


K. Knepper, C. Gil and S. Brase   Pages 673 - 691 ( 19 )


High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.


combinatorial synthesis, total synthesis, natural product, solid-phase, heterocycles, high throughput screening, genomic


Institut für Organische Chemie, Universität Karlsruhe, Fritz-Haber-Weg 6, D-76131 Karlsruhe,Germany.

Read Full-Text article