K. Knepper, C. Gil and S. Brase Pages 673 - 691 ( 19 )
High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.
combinatorial synthesis, total synthesis, natural product, solid-phase, heterocycles, high throughput screening, genomic
Institut für Organische Chemie, Universität Karlsruhe, Fritz-Haber-Weg 6, D-76131 Karlsruhe,Germany.