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Multicomponent One-Pot Reactions: Synthesis of Some New 6-Oxopyrano [2,3-c]Isochromenes by Condensation of Homophthalic Anhydride, Dialkyl acetylenedicarboxylate, and Isocyanides

[ Vol. 12 , Issue. 5 ]

Author(s):

Ali A. Mohammadi, Roya Akbarzadeh and Hamed Rouhi   Pages 536 - 542 ( 7 )

Abstract:


A novel three-component, one-pot condensation of the zwitterion generated from dialkyl acetylenedicarboxylate and isocyanides with homophthalic anhydride is described. The reaction affords new 6-oxopyrano[2,3- c]isochromenes in good yield. Isochromenes have been reported to possess diverse biological activities such as antibacterial, antifungal, antiinflammatory, and antiangiogenic effects. Moreover, Theses important compounds are found in various natural products.

Keywords:

Multi-component reaction, isocyanide, dialkyl acetylenedicarboxylate, homophthalic anhydride, isochromenes

Affiliation:

Department of Chemistry, Shahid Beheshti University, Tehran, Iran.



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