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A Comprehensive Review of Monoamine Oxidase-A Inhibitors in their Syntheses and Potencies

[ Vol. 23 , Issue. 9 ]

Author(s):

Nisha A. Rehuman, Bijo Mathew*, Rakesh K. Jat, Orazio Nicolotti and Hoon Kim*   Pages 898 - 914 ( 17 )

Abstract:


Background: Monoamine oxidases (MAOs) play a crucial role during the development of various neurodegenerative disorders. There are two MAO isozymes, MAO-A and MAO-B. MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine.

Materials and Methods: Focus on synthetic studies has culminated in the preparation of many MAOA inhibitors, and advancements in combinatorial and parallel synthesis have accelerated the developments of synthetic schemes. Here, we provided an overview of the synthetic protocols employed to prepare different classes of MAO-A inhibitors. We classified these inhibitors according to their molecular scaffolds and the synthetic methods used.

Results: Various synthetic and natural derivatives from a different class of MAO-A inhibitors were reported.

Conclusion: The review provides a valuable tool for the development of a new class of various selective MAO-A inhibitors for the treatment of depression and other anxiety disorders.

Keywords:

MAO-A, MAO-B, inhibitors, neurotransmitters, molecular scaffolds, neurodegenerative disorders.

Affiliation:

Department of Pharmaceutical Chemistry, JJTU University, Jhunjhunu, Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi-682, Department of Pharmaceutical Chemistry, JJTU University, Jhunjhunu, Dipartimento di Farmacia-Scienze del Farmaco, Universita degli Studi di Bari “Aldo Moro”, via E. Orabona, 4, I-70125 Bari, Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922



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