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On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

[ Vol. 4 , Issue. 3 ]

Author(s):

Liang Tang, William. L. Fitch, Peter Smith, David Tumelty, Kathy Cao and Steven W. Ferla   Pages 287 - 293 ( 7 )

Abstract:


An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.

Keywords:

High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel

Affiliation:

Department of Pharmacology and Preclinical Development. 2 Corporate Drive, South San Francisco, CA 94080, USA.



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